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The first 12 to 24 hours post-injection carry the highest side effect burden, and combining that with physical exertion compounds nausea significantly
When stratified by cooccurring medical conditions, those with type 2 diabetes were 49% less likely to have a recorded alcohol intoxication episode, while those with obesity and both type 2 diabetes and obesity were 42% less likely, relative to those without a semaglutide/tirzepatide-type medication prescription
Insulinotropin: glucagon-like peptide I (737) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
Drugs with narrow therapeutic windows (warfarin, levothyroxine, oral contraceptives, certain seizure medications) deserve clinician oversight
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![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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