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GLP-1 medications are eliminated through renal pathways, and reduced kidney function affects both drug tolerance and the risk of complications particularly dehydration-related acute kidney injury, which can occur when GI side effects (nausea, vomiting) reduce fluid intake

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Zhmud et al., 2023)

Treatments for NHIC typically aim at protecting the bladder lining and modulating nerve activity to reduce pain and discomfort (Jhang et al., 2022)