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2 Incidence in both sexes increases with age and can be asymptomatic it is estimated that up to 30% of people living in nursing homes and other institutions have asymptomatic bacteriuria

Using redox cycling quinones to increase production of hydrogen peroxide and by measuring transcription by nuclear run-on analysis, it was then shown that a sustained increase the amount of GSH in cells could be achieved by increasing the transcription of GCLC (Shi et al., 1994

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Additionally, some studies have small sample sizes or lack sufficient power to detect meaningful clinical differences, while others fail to control for confounding factors such as concurrent antioxidant therapy, severity of illness, and pre-existing nutritional deficiencies