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Konopka et al., 2020), cytoplasmic mislocalization of nuclear proteins (Neumann et al., 2006), mitochondrial dysfunction (Albers and Beal, 2000), glutamate excitotoxicity (Shaw and Ince, 1997), proteasomal and autophagic dysfunction (Chen et al., 2012), ER stress (Nagata et al., 2007

If it were a breakthrough fat-loss drug, it would likely still be in aggressive pharmaceutical development

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