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R.et al (2017)

Obesity is a significant health risk, as it increases the risk of developing cardiovascular diseases, diabetes, hypertension, and other medical conditions

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This focus led to significant breakthroughs, but it became clear in animal models that single-pathway stimulation had a ceiling effect regarding metabolic stabilization and lipid management

A commenter stated that the measure has not been tested with a self-administration option and recommended testing self-administration and resolving barriers prior to adopting this measure