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Sphingolipid metabolites, such as sphingosine 1-phosphate, play a crucial role in the modulation of inflammatory diseases ( Furthermore, we observed that the level of spermidine was higher in the plasma of patients with MS than in healthy controls

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Results Acute COVID-induced brain fog is associated with BBB dysfunction We collected serum and plasma samples from 76 inpatients with acute COVID-19 recruited as part of the St Jamess Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers Bioresource collection during the initial wave of COVID-19 in March and April 2020 (Extended Data Fig