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(247) demonstrated that Bifidobacterium strains effectively restore immune homeostasis in colitis models by upregulating regulatory T cell populations, which directly correlates with reduced tissue damage

239,240 In summary, GLP-1 lowers blood glucose levels and inhibits glucagon secretion through direct action on -cells, promotion of insulin secretion, and regulation of gastrointestinal activity

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Very common adverse effects (reported in more than 10% of participants in SURMOUNT-1): Rare but serious risks: Absolute contraindications: personal or family history of medullary thyroid carcinoma (MTC), Multiple Endocrine Neoplasia type 2 (MEN 2), active pancreatitis, and known serious hypersensitivity to tirzepatide or any excipient