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Such off-label use, i.e., made in the absence of an FDA approval for this indication, in itself is reason for carefully conducted, evidence-based clinical trials, say the researchers, who reported results in JAMA Psychiatry

This increase cannot be explained through hereditary factors as most early onset colon cancers are sporadic, meaning not linked to passed-down genetics

Nutrients 15, 811 (2023)

such antibodies Upon administration to an animal or patient with a vascularized tumor, such antibodies localize to the malignant cells by virtue of the fact that vascularized tumors naturally contain necrotic tumor cells, due to the process(es) of tumor re-modeling that occur in vivo and cause at least a proportion of malignant cells to become necrotic

An alternative strategy involves engineered probiotics as living nanofactories that secrete GLP-1 analogues directly in the gut [390, 391]