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attenuated (but not zero) pigmentary effects at high doses
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Mago, T
Despite the guideline-recommended use of both SGLT2i and GLP-1RA therapy, there is a paucity of real-world evidence on the long-term effects of combining SGLT2is with newer generation GLP-1RAs (including once-weekly GLP-1RAs, once-daily oral semaglutide, and dual GLP-1/glucose-dependent insulinotropic polypeptide [GIP] agonists) on metabolic outcomes and other cardiorenal outcomes [22]
The common denominator: a wider bioenergetic safety margin Across all three families, the convergence is clear: lower oxidative stress, improved coupling efficiency, cleaner substrates, and more stable ion handling
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