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Theory and research application of the reserve concept

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While AOD9604 has not achieved the commercial success initially envisioned, it has contributed valuable insights into the dissociable functions of different regions of the growth hormone molecule and has validated the concept that targeted metabolic effects can be achieved without unwanted growth hormone receptor activation

Rodenburg J, Vissers MN, Wiegman A, Miller ER, Ridker PM, Witztum JL, Kastelein JJ, Tsimikas S