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These findings suggest that the effects of SGLT2 inhibitors extend beyond hemodynamic improvements, involving direct modulation of intracellular pathways implicated in kidney injury

Essential covariates collected in this study included information on demographics (age, gender, education, marital status, and the ratio of family income to poverty (PIR)), behavioral factors (including physical activity, smoking), medical conditions (including diabetes, prednisone or cortisone intake), menstrual status, healthy eating status (including vitamin D supplement, milk consumption), and serum markers (including albumin, alkaline phosphatase, total calcium, and phosphorus)

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Nevertheless, the consistent theme in patient before-and-after photos and reports is an improvement in skin firmness and hair quality over a period of weeks to months