is metformin same as semaglutide vs Efficacy and Safety of Once-Weekly Versus Once-Daily Sitagliptin Add-on in a Korean Population with Type 2 Diabetes Semaglutide vs. Metformin vs. Tirzepatide

Tsapas A, Avgerinos I, Karagiannis T, Malandris K, Manolopoulos A, Andreadis P, Liakos A, Matthews DR, Bekiari E

In general, intensification of treatment beyond two medications follows the same general principles as the addition of a second medication, with the assumption that the efficacy of third and fourth medications will be generally less than expected

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In the pancreas, GLP-1 binding to its receptors stimulates the secretion of insulin, which helps to lower blood sugar levels