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subtilis is a Gram-positive bacterium commonly found in soil and decomposing organic matter and was among the first organisms to have its genome fully sequenced and annotated [58, 59]

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doi: 10.3389/fendo.2011.00032 84 GarmesHMCastilloARMonte AlegreSde SouzaALAtalaYBZantut-WittmannDE

This latter observation suggests that native pairing, while stabilizing the antibody structure and functional paratopes, does not necessarily reduce its propensity to partially unfold and expose hydrophobic residues that are traditionally buried in its native state