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As of 2026, no peer-reviewed human clinical trials on FOXO4-DRI have been published

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3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines

In addition they suggest that the BSOr mutants are more resistant to heat inactivation than the wt virus and less dependent on GSH than the wt, likely because the BSOr capsids are more stable

Acknowledgments Numerous former members of the Mannervik laboratory have contributed to the cited work