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This review offers a comprehensive synthesis of recent advancements in the investigation of antioxidants for the treatment of DN, with a particular focus on their clinical application, molecular mechanisms and potential therapeutic applications

Increased knowledge of how bacteria and bacterial products such as endotoxin cross the epithelial barrier should yield data that facilitate the discovery of treatments aimed at abrogating the most feared complications of systemic endotoxemia, namely SIRS and MOF, whereas further study of paracellular permeability could likely lead to breakthroughs in the prevention of toxigenic diarrhea, a cause of substantial morbidity and mortality worldwide [87]

Intracellular antioxidant to protect against oxidative stress

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