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Significantly, the expression of RAGE is markedly upregulated under various pathological circumstances, especially in atherosclerosis, diabetes mellitus, CVD, RA, Alzheimer's disease (AD), and immunerelated disorders [229,230,231,232,233]

The synergistic effects of these agents on monoaminergic modulation, neurotrophic signaling, inflammatory responses, oxidative stress management, and stress-response mechanisms provide a compelling mechanistic foundation for their therapeutic significance in the treatment of depressive disorders

This anionic linker has higher water solubility than traditional linkers and has excellent cycle stability

(2003) Insulin resistance in the liver-specific IGF-1 gene-deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-1 in insulin resistance

Br J Pharmacol 147(S1):S252S7