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In cases where encapsulation efficiency is low, patients may not receive the intended dose of the drug, leading to suboptimal treatment efficacy [343]

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Lawrence, M.S., et al., Mutational heterogeneity in cancer and the search for new cancer-associated genes

A number of currently available ferroptosis modulators also face limitations in drug-like properties, such as poor water solubility, instability and suboptimal pharmacokinetics, which hinder their development into clinically viable agents (141)

Because they work in delicate concert with one another, added stress sends these energy centers into overdrive, eventually lowering their function