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The Big Picture Despite the potential for side effects like gastroparesis and SIBO, semaglutide offers huge benefits

Semaglutide-related fatigue primarily occurs due to dramatically reduced calorie intake as appetite suppresses, rapid weight loss causing metabolic adjustments, possible dehydration from eating and drinking less, inadequate protein consumption leading to muscle loss, blood sugar changes particularly in people with diabetes, and possible sleep disruptions

Especially when starting treatment or following an uptick in dosage, individuals may observe an uptick in how often they need to use the bathroom

The primary endpoint was a 2-point improvement in the NAS without worsening of fibrosis

This applies to everyone, but especially to semaglutide users whose gastric motility is already altered