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The MHRA has emphasised that topiramate should not be used for weight loss, and its use in pregnancy for migraine is contraindicated

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2.4 Metabolic and mitochondrial dysfunction in diabetes An animal experiment using db/db mice, a model of type 2 diabetes, demonstrated that disturbances in circulatory metabolism and brain energy metabolism, particularly mitochondrial dysfunction, may contribute to cognitive impairment

7 12 Bloating during GLP-1 therapy is caused by delayed gastric emptying, and specific probiotic strains like B