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Doses of semaglutide ranging from 0.1-1.6 mg resulted in a 2.1%, 7.0%, 13.0%, 37.5%, 51.2%, and 63.6% respective dose-dependent increases in the proportion of patients that achieved a 5%, or greater, reduction in weight loss

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However, in severe hepatic impairment or cirrhosis, the BNF and SmPC advise caution: the dose interval should be increased to at least every 6 hours, and the maximum daily dose may need to be reduced

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