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Reduction in HbA1c with SGLT2 inhibitors vs DPP-4 inhibitors as add-ons to metformin monotherapy according to baseline HbA1c: a systematic review of randomised controlled trials

Our analysis of the collected data revealed that psychiatric AEs were most frequently reported in relation to diabetes ( n = 5,286, 64.15%) and weight control ( n = 332, 4.03%)

As such, they are an important antioxidant defense in nearly all cells exposed to oxygen

Disease severity is likely dependent on the efficiency of alternative pathways, but not on the level of residual enzyme activity (25)