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As a first data exploration, orthogonal partial least squares discriminant analysis (OPLS-DA) was employed to inspect the discriminant capacity of plasma and erythroid metabolites in a multivariate manner

Mohs RC, Davis KL, Tinklenberg JR, Hollister LE

Small clinical studies suggest it may provide pain relief and functional improvements, but the lack of standardized protocols and high-quality RCTs limits clinical adoption (34)