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Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor

These inflammatory mediators not only exacerbate neuronal injury but also contribute to BBB disruption, leading to cerebral edema and hemorrhagic transformation

Beyond its direct antioxidant capabilities, glutathione plays a mandatory role in the Phase II detoxification of heavy metals and environmental pollutants

The nonenzymatic initial reaction between 1 M roGFP2 WT (S 2 ) and physiological millimolar GSH concentrations was too slow to be detectable and to be of any relevance in the presence of glutaredoxins in accordance with previous analyses 32

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