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The main eligibility criteria for weight in the STEP 1, 3, 4, and 5 trials were BMI 30 kg/m 2 or BMI 27 kg/m 2 with at least one weight-related comorbidity (hypertension, dyslipidemia, obstructive sleep apnea, or CVD), while patients in STEP 2 had to have a BMI 27 kg/m 2 and T2D

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In these studies, insulin was discontinued, and patients were started on liraglutide at a low dose, which was subsequently titrated based on tolerance and need

Therefore, fatigue could possibly be relieved by restoring serum carnitine levels through supplementation 641