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It is the idea that the brain learns to like the drug, or makes it a habit

Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro

Durand E, Laguerre M, Bourlieu-Lacanal C, Lecomte J, Villeneuve P

Additional analysis was performed to estimate the association of body weight reduction on changes in HOMA2-IR (computed with insulin) with tirzepatide

That is encouraging because it suggests retatrutide may improve body composition without showing a disproportionate lean-mass penalty despite strong weight-loss effects

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