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In fact, the TLR4 ligand lipopolysaccharide is reported to induce epigenetic reprogramming of haematopoietic stem cells, leading to persistent changes in the accessibility of their myeloid lineage enhancers (234)

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The grids were stained with 0.8% (w/v) uranyl formate solution and imaged using cryo-EM Tecnai T12 TEM at 120 kV