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Protein structural characterization methods all have limitations

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Moreover, in models of ischemiareperfusion injury and in KEAP1-inactivated lung cancer, inhibition or genetic ablation of CoQ biosynthetic enzymes restored sensitivity to ferroptosis or radiotherapy 115,116 , underscoring the reliance of some cancer cells on an abundant CoQ pool for redox defense and survival

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Incretin-based therapies (GLP-1 receptor agonists and DPP-4 inhibitors) enhance insulin secretion in a glucose-dependent manner , which greatly reduces the risk of hypoglycemia