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A three-year randomized, double-blind, placebo-controlled trial in 818 older adults (aged 50-70 years) with elevated homocysteine levels but normal serum vitamin B 12 levels found that folic acid supplementation (800 g/day) lowered homocysteine levels and improved measures of memory performance (115)

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Additionally, PD patients present deficiencies in mitochondrial complex I in the SN, suggesting that a defect in this complex could contribute to neuronal degeneration in PD [25]

ii) Anti-inflammatory and anti-fibrosis therapy should be considered in some patients with cirrhosis for whom etiological therapy is not available, or for whom liver inflammation or fibrosis remains severe after etiological therapy