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In the AMY 3 R consensus maps, density allows potential modelling of an alternate rotamers of F23 Cagri in antiparallel with Y146 1.37 (Supplementary Fig

The results imply that even residues not directly involved in the interaction may exhibit changes in their chemical environment if they are adjacent to residues crucial for the interaction or undergo conformational changes upon binding 39,40

These research-stage amylin-based candidates differ in receptor focus, molecular design, clinical evidence, side-effect profile, and development strategy

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