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While the use of NK1R antagonists is being tested in several clinical trials for the treatment of other pathologies (110, 111), further studies are needed to fully elucidate the role of SP and its receptor in HSV-1 eye infections and their potential therapeutic uses

23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

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Unfortunately, certain gaps in knowledge preclude our ability to accurately label NADPH as good or bad