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Gilligan T, et al

In 2014, it was also approved for the treatment of obesity, whereas tirzepatide was first approved by the FDA in 2022 for the treatment of T2DM

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These processes not only compromise cellular bioenergetics but also trigger immune responses through sensors such as cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING), or activate NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasomes, leading to secretion of proinflammatory cytokines such as interleukin (IL)-1 (Mills et al., 2017)

The positive control pair BCL2L1 x MCL1 exhibited the expected synthetic sick genetic interaction as previously reported across all conditions (Fig