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Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4(+) CD8(+) T suppressor cells that protect from collagen-induced arthritis (CIA)

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Leaky gut and bone and joint autoimmunity Leaky gut syndrome has also been found to contribute to the development of autoimmune reactions targeting bone and joint tissue

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And in the context of GH biology, overshooting carries consequences: IGF-1 excess has associations with insulin resistance, fluid retention, and in some populations, oncological risk