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A 2022 review in Frontiers in Neuroscience (Klausen et al.) and a 2023 study in Translational Psychiatry (Leggio et al.) both explored these mechanisms, finding plausible biological explanations for reduced alcohol motivation in GLP-1 users

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GLP-1 RAs, originally developed for glycemic control in type 2 diabetes, have demonstrated mechanistic plausibility and emerging clinical efficacy in modulating key pathophysiological processes implicated in depression, including insulin resistance, neuroinflammation, and reward system dysregulation

March 2022

Unlike the well-known roles of GLP-1 and #PYY, the role of INSL5 is poorly understood, but this new research suggests it promotes colonic motility and in fact may be behind the cases of severe diarrhea (bile acid malabsorption in #IBS)