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GIP/GLP-1 SGLT2DPP4GLP-1 GIP/GLP-1 GIP/GLP-1 GIP/GLP-1 GIPglucose-dependent insulinotropic polypeptide: GLP-1glucagon-like peptide 1: -1 GLP-1 5mg 1.0mgSURPASS-25mg1mg-7.6kg15mg-11.2kg SURPASS-21mg5mg/40HbA1c2%HbA1c2% N Engl J Med 385(6):503-15,2021. 2SRPUSS J-monoHbA1c7.067HbA1c 7.094 GIPGLP-1 111 GIP/GLP-12023 2022 SURPASS-J-mono GLP-1 / 9 FORTUNE DREAM

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Pharmacological characterization To examine whether the potent weight loss observed in vivo after GLP-1MK-801 treatment is attributable to pharmacological synergy between GLP-1 and MK-801 or consequential to altered pharmacokinetic properties of the parent GLP-1 analogue, we designed and synthesized a conjugate comprising an inactive MK-801 surrogate 22 (Supplementary Fig

Qsymia has become a second-line option, recommended when GLP-1 medications are not tolerated, not accessible, or contraindicated