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Semaglutide is a single-target GLP-1 receptor agonist, a different mechanism from dual GIP/GLP-1 agonists like tirzepatide

Incorporating GLP-1 analogues into these platforms may enable synergistic metabolic and immunomodulatory effects

However, a high-fat diet and subsequent development of NASH can downregulate hepatic GLP-1R expression, thereby inducing therapeutic resistance to this medication in certain patients (Svegliati-Baroni et al., 2011

The result is that patients on weight loss medications often need to be more intentional about fluid intake than they were before starting treatment

It means they need time and the right conditions to recover