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10.1038/s41418-017-0012-4 Cell Death Differ

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In contrast, very large supplemental doses of pyridoxine 2,000 mg per day or more are linked to sensory nerve damage and skin lesions ( High intake of pyridoxine supplements may also suppress milk production in breastfeeding women ( Benefits of Supplements Large doses of pyridoxine have been used to treat carpal tunnel syndrome and premenstrual syndrome