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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily prescribed for the management of type 2 diabetes mellitus and, more recently, for weight management in adults with obesity

We need to acknowledge the complexity of the disease [of obesity] and the complexity of well-managed care, and that the relationship between the two is key. Tracy Zvenyach GLP-1s Are Safe Although GLP-1s have only recently become well-known to the public, they have been used to treat diabetes for 20 years, and there are many studies that show that these drugs are both safe and effective

It may be too early to make material adjustments to those assumptions for AOMs, but they increase confidence in future mortality and morbidity improvements

doi:10.1046/j.1365-201x.1996.33260000.x

For example, if genetic testing shows you carry high-sensitivity variants in GLP1R, your provider might recommend an even slower dose ramp-up or oral tirzepatide as an alternative, since oral formulations generally produce less severe nausea than injections