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In preclinical and mechanistic literature, this signaling axis has been studied for its role in: neuronal structure dendritic branching synaptic organization cellular communication and structural plasticity Because of this pathway association, Dihexa has drawn attention in laboratory settings where researchers are evaluating signal transduction, synaptic density, neurite outgrowth, and network-level structural organization in non-human test systems

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& Thompson, C

Ryan S, Taylor CT, McNicholas WT (2009) Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome