This disorder arises from impaired lymphatic drainage due to either congenital abnormalities (primary lymphedema) or acquired damage to the lymphatic system (secondary lymphedema)
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Alpha-lipoic acid Increased oxidative stress caused by free radical formation and defects in antioxidant defense related to hyperglycemia is thought to cause endoneurial hypoxia and nerve dysfunction, which contribute to DPN [61]
UK-5099 (PZ0610, Sigma), Erastin (E7781), N-acetyl-cysteine (A7250), GSH-MEE (353905), NADH (N8129), dTMP (T7004), CMP (C1131), and ATP (A-6419) were purchased from Sigma