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In some cases, symptoms are driven more by how the body responds to normal hormonal fluctuations than by abnormal hormone levels themselves.16 Because of this, supplements may be most useful for people dealing with recurring, pattern-based symptoms such as mood changes around the menstrual cycle, persistent fatigue, irregular periods, or hot flashes even when lab values fall within normal ranges

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women with endometriosis also had lower levels of the endogenous antioxidant superoxide dismutase in their plasma (Prieto 2012)