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It works by binding to GHRH receptors in the pituitary gland, stimulating the natural release of human growth hormone (GH), which then increases circulating levels of IGF-1 (Insulin-like Growth Factor-1)

ROS participate in this process by modulating signal transduction pathways that promote tyrosine phosphorylation, a key event in sperm activation ( In addition to lipid peroxidation, oxidative stress induces protein oxidation, which affects the function of key proteins involved in sperm motility and structure ( Oxidative stress in spermatozoa can originate from both internal and external sources

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This finding highlights disrupted redox balance and the accumulation of reactive oxygen species (ROS) in COVID-19, suggesting that the antioxidant system plays a crucial role in mitigating inflammation and preventing organ failure