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Abstract Current pharmacological treatments for bipolar disorder are inadequate and based on serendipitously discovered drugs often with limited efficacy, burdensome side-effects, and unclear mechanisms of action

Ongoing clinical studies aim to better understand tirzepatides full spectrum of benefits beyond glycemic control, including its role in managing migraines and autoimmune diseases like Hashimotos

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While retatrutide shares some common side effects with GLP-1 receptor agonists, such as gastrointestinal events, the frequency and severity of these adverse events appear to be dose-dependent and can be partially mitigated by the use of a lower starting dose