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In plain English: It turns off the gene that produces pain and inflammation

PubMed, Embase, and the Cochrane Library were searched using keyword combinations related to GLP-1 receptor agonists, dual GLP-1/GIP agonists, and GI adverse events, from the inception of the database up to March 2025

185 Ironically, HSP70 can act as a damage-associated molecular pattern (DAMP), eliciting anti-tumor immune responses

Ocular hypertension triggers the production of pro-inflammatory cytokines by immune cells, which in turn drives the transformation of neuroprotective astrocytes into a neurotoxic A1-reactive phenotype, ultimately leading to RGC degeneration [45]

This finding is sometimes cited to justify ipamorelin use in corticosteroid contexts, but that extrapolation is not supported by available evidence