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GLP-1 is secreted by L cells in the ileum and GLP-1 receptors are found on the beta cells of the pancreas, in the intestine, and in the hypothalamus

Now, that food has been stripped of its fiber, and those bacteria get so hungry they eat the mucin barrier off our intestinal cells, setting us up for inflammation and leaky gut. A calorie is a calorie

Most common tirzepatide side effects include: Nausea Diarrhea Decreased appetite Constipation Vomiting Indigestion or bloating Symptoms often appear during dose increases and typically improve over time

References Kobor, Michael S., and Joanne Weinberg