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doi: 10.1002/art.39685 111 YinYWangMLiuMZhouERenTChangXet al

These multimers promote vascular intima injury, which increases endothelial permeability, monocyte adhesion, and macrophage accumulation, leading to plaque development ( The polyol pathway consumes up to 30% of intracellular glucose under hyperglycemic conditions, with aldose reductase converting glucose to sorbitol in an NADPH-dependent reaction that depletes this critical cofactor required for glutathione reductase activity ( 2 - while triggering pro-inflammatory NF-B signaling (Yan et al., 2023)

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10.1161/CIRCRESAHA.108.190611 Circ Res