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and have important effects on lipid metabolism and insulin sensitivity [209] in human [115,116] and animal models [116,112]

FIGURE 3 The immunopharmacological effects of GSH are evident through several distinct but interconnected pathways, including regulation of inflammatory signaling networks like MAPK and NF-B, buffering of pathologic ROS as well as maintenance of cellular ROS signaling, and modulation of both peripheral and central immune cell activity (Peterson et al., 1998)

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10.5152/npa.2014.7213 120 ShiH