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Pediatr Allergy Immunol 17:291296 Rossignol DA, Frye RE (2014) Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism

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37 Available data suggest that increased visceral fat, rather than obesity per se , induces MS by triggering cytokine release from macrophages, activating inflammatory signaling cascades, and causing the accumulation of reactive oxygen species (ROS) resulting from endoplasmic reticulum (ER) dysfunction

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