NSAID Interference with Aspirin's Antiplatelet Effects As illustrated in Figure 3, non-aspirin NSAIDs can interfere with aspirin's ability to gain access to its COX-1 binding site by steric interference(2 drugs can't occupy the same active site at the same time), thus reducing aspirin's antiplatelet effects when the two drug types are taken concomitantly
Mood changes, if they happen, are more likely an indirect effect of the medication
For health care professionals, it is important to address issues like stomach pain and changes in blood sugar
Lack of safety data remains the fundamental concern
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