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SQS is an enzyme involved in the synthesis of cholesterol, which leads to the depletion of the endogenous antioxidant Coenzyme Q10 (CoQ10), a non-steroidal metabolite in the glutaric acid pathway

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Glucagon-like peptide-1 receptor agonist treatment reduces beta cell mass in normoglycaemic mice

Given retatrutide's investigational status and its observed effects on blood pressure and heart rate, certain patient populations would require particularly careful evaluation before any future use, should the agent receive regulatory approval