LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition
Cheng, B., Sun, C., Li, S., Gong, Q
Originally developed as an anti obesity compound, it has become a widely used research tool for studying fat metabolism, lipolysis, and more recently cartilage repair, valued particularly for its ability to mimic the fatmetabolizing activity of growth hormone without the broader hormonal side effects that come with it
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Discussion In the present investigation, we demonstrate for the first time that the decreased glutathione-mediated redox/antioxidant capacity previously observed in plasma and immune cells from children with autism is also significantly decreased in two brain regions previously shown to be affected in autism, the cerebellum and BA22